The research at DRILS is supported in part by Institutional/Industry sponsorship and significantly by grants from Government agencies. Scientists at DRILS submit competitive grant proposals and routinely obtain multiple rounds of funding from agencies such as DBT, DST, SERB, ICMR and CSIR. The following is a list of current grants-
Ongoing Grants
| Title | Agency | PI, Co-PI’s | Duration |
| Identification of the mechanistic basis of early striatal damage in Glutaric Aciduria Type I | DBT | Aarti Sevilimedu, Pushkar, Radha Rama Devi | 2018-2021 |
| Use of DNAzymes to improve CRISPR-mediated knock-in | DBT GET | Kiranam Chatti, Aarti Sevilimedu | 2018-2021 |
| Molecular analysis of the functional role of ser/thr phosphatase PHLPP in lipid induced formation of foam cells, a hallmark of atherosclerosis | DBT | Kishore Parsa, Kiranam Chatti | 2019-2022 |
| Identification of optimal therapeutic window for efficacious intervention in a Zebrafish model of Fragile X syndrome. | DBT | Aarti Sevilimedu, Kiranam Chatti, Pushkar Kulkarni | 2019-2022 |
| A Microneedle Transdermal Patch for Supplementing Critical Micronutrients for Prevention and Control of Anemia | DBT Public Health and Nutrition | Marina Rajadurai, Parimal Misra, B.R. Shamanna, C. T. Anitha | 2020-2023 |
| Molecular characterization of the functional role of ser/thr phosphatase PHLPP in pancreatic beta cells to gain mechanistic insights into diabetes | SERB | Kishore Parsa Parimal Misra, Pushkar Kulkarni, Prakash Babu (UoH) Sasiskala M (AIG-AHF) |
2020-2023 |
| Understanding the functional role of co-activator binding protein PIMT in adipogenesis and obesity | DBT | Parimal Misra, Kishore Parsa, Satyamoorthy, Manjunath Joshi (MAHE) |
2020-2023 |
| Studies on the role of HDAC inhibitors in reprogramming cancer cell metabolism to reverse cisplatin resistance in patient derived xenograft model of ovarian cancer. | ICMR | Prasenjit Mitra, Manjunath Joshi, Naveena AN Kumar, Vasudha Devi (MAHE) | 2021-2024 |
| Understanding the regulatory role of co-activator binding protein PIMT in the pancreatic b-cells of diabetic animals and T3C diabetic (Chronic pancreatitis) humans | DST-SERB | Parimal Misra, Kishore Parsa, Partha Chakrabarti (IICB, Kolkata), Sasikala M (AIG) | 2021-2024 |
| Center for Rare Disease Diagnosis, Research and Training | IndiaAlliance/Wellcome-DBT | Aarti Sevilimedu, Girisha KM (MAHE), Dr. Akhilesh Pandey (IOB ), | 2021-2026 |
Completed Grants
| Title | Agency | PI, Co-PI’s | Duration | Status |
| Virtual Centre of Excellence: Multi-disciplinary approaches aimed at intervention of Mycobacterium tuberculosis | DBT | Seyed E. Hasnain (UoH) | 2008-2013 | Completed |
| Small molecule inhibitors of mycobacterial menaquinone biosynthetic pathway enzymes as novel anti – tubercular agents | CSIR | Anil K.Krutiventi, Ritta Mathew | 2009-2011 | Completed |
| Virtual Centre of Excellence on Multidisciplinary approaches aimed at interventions against Mycobacterium tuberculosis (Phase 1), Project: Molecular inhibitors targeting essential enzymes like Chorismate mutase as potential new drug(s). | DBT | Manojit Pal Parimal Misra Seyed E Hasnain |
2009-2014 | Completed |
| Phosphoproteomic analysis of tyrosine kinase signaling | DST (SERB) | Kiranam Chatti | 2009-2012 | Completed |
| Investigating the role of 9-O-acetylated sialic acids during early embryonic development | DST (SERB) | Anilkumar Challa | 2009-2012 | Terminated (PI relocation) |
| Identification and Characterization of PTEN regulators | DBT | Subba Reddy Maddika | 2009-2012 | Transferred (PI relocation) |
| Design, Synthesis, and Biological Evaluation of Pharmaceutically Acceptable PTP-1B Inhibitors | DST (SERB) | Sreedhara Voleti, Ghanshyam Swarup (CCMB) | 2010-2013 | Completed |
| Dual Conjugation of Cationic Lipids and Cell Penetrating Peptides to dsRNA Oligonucleotides for In Vivo siRNA Delivery | DBT | Prasenjit Mitra, Rajamohan Poondra, Pradeep Kumar P (IIT-B) | 2010-2013 | Completed |
| Study the role of protein tyrosine phosphatase non-receptor type 18 (PTPN 18) in regulation of localization of histone deacetylase 4 (HDAC4) | DST (SERB) | Arunasree Kalle | 2010-2013 | Terminated (PI relocation) |
| Embryonic zebrafish as a model system to study the expression and role of breast tumour kinase | DBT | Kiranam Chatti | 2010-2013 | Completed |
| Understanding the role of PHLPP in IFNγ-mediated innate immune responses of macrophages | DBT | Kishore Parsa Nasreen Ehtesham Seyed E Hasnain (IIT-D) | 2010-2013 | Completed |
| Molecular analysis of the role of PHLPP1 in macrophage inflammatory response | CSIR | Kishore Parsa | 2010-2013 | Completed |
| Rational design and synthesis of novel antibiotics against drug resistant bacteria | DST (SERB) | Marina S. Rajadurai | 2010-2013 | Completed |
| Palladium mediated synthesis of heterocyclic compounds of potential biological interest | DST (SERB) | Manojit Pal Rajmohan P | 2010-2013 | Completed |
| A Chemical Biology Approach to Discover Allosteric Modulators of Glucagon Like Peptide-1 Receptor (GLP-1R) | DST (SERB) | Prabhat Arya Prasenjit Mitra | 2010-2013 | Completed |
| Synthesis of novel drug-like scaffolds by diastereoselective intra-molecular aza-Diels-Alder cyclization based on α-aminoacid and vanillin precursors | DST (SERB) | Neelima D. Tangellamudi | 2010-2013 | Completed |
| Design, synthesis and identification of phosphodiesterase 4 (PDE4) inhibitors possessing improved safety profile | DBT | Manojit Pal Kishore Parsa | 2010-2011 | Completed |
| A Suppressor screen to uncover novel functions of fission yeast S.pombe sirtuin Hst4 | DBT | Devyani Haldar | 2010-2013 | Completed |
| Understanding the Transcriptional Regulation and Identification of global regulators of PE/PPE genes of Mycobacterium tuberculosis | DBT | Vaibhav Vindal (UoH) K. Mohareer | 2011-2013 | Completed |
| Development of Nature-Inspired Small Molecules to Modulate Prostaglandin Pathway: Exploration of Haematopoietic Stem Cell Biology in Zebrafish | DST (SERB) | Rajamohan Poondra, Kiranam Chatti | 2011-2014 | Completed |
| Identification of novel Akt-interacting partners and investigation of their role in LPS-induced macrophage inflammatory response | DAE | Kishore Parsa | 2011-2014 | Completed |
| Understanding the role of transcriptional co-activator binding protein PIMT in the control of hepatic gluconeogenesis | DBT | Parimal Misra Kishore Parsa | 2011-2014 | Completed |
| Synthesis of Fluorescent Saccharide Sensors as Potential Tool for the Diagnosis of Carbohydrate Metabolism Disorders | CSIR | Marina S. Rajadurai | 2011-2014 | Completed |
| A yeast based screen for discovery of novel sirtuin inhibitors as anti-cancer agents | DBT | Devyani Haldar Manojit Pal | 2011-2013 | Completed |
| A Chemical Biology Approach to Discover Allosteric Modulators of Sirtuins and to Understand their Mode of Action | DBT | Prabhat Arya Parimal Misra Arunasree K | 2011-2013 | Completed |
| Development of a noninvasive method using saliva from patients for detection of a early onset of type 2 diabetes | ICMR | Prasenjit Mitra S. Ahmed Ibrahim (NIN) Anupama Row (UoH) | 2011-2013 | Completed |
| Regulation of Breast Tumour Kinase (BRK) activity by its alternately spliced form lm5 | CSIR | Kiranam Chatti | 2011-2012 | Completed |
| Molecular analysis of the functional role of miR-7 in β-cells | DST (SERB) | Kishore Parsa | 2012-2015 | Completed |
| Identification of quorum sensing regulators in Mycobacterium tuberculosis | DST (SERB) | Krishnaveni Mohareer | 2012-2015 | Completed |
| Natural product-inspired macrocyclic architectures: Novel therapeutic agents in medicinal chemistry | DST (SERB) | Naveen Mulakayala | 2012-2015 | Terminated (PI relocation) |
| Understanding Cut4 and PknA phosphorylation in biofilms of Mycobacteria | DST (SERB) | Ritta Mathew | 2012-2015 | Transferred (PI relocation) |
| Developing and validating a single protocol based zebrafish model for preclinical safety assessment of nanotherapeutics | DBT | Pushkar Kulkarni Kiranam Chatt | 2013-2016 | Completed |
| Synthesis of marine natural products based compounds of potential biological significances | MoES | Manojit Pal J. Iqbal Rajmohan Poondra | 2013-2014 | Completed |
| Understanding the functions of Selective AMPKγ Modulators (SAMPKγM) in dissecting the pharmacological role of different AMPK isozymes in metabolic diseases | DBT | Parimal Misra Rajmohan Poondra Sreedhara R Voleti | 2014-2017 | Completed |
| Design and development of novel phosphodiesterase 4 (PDE4) inhibitors | DBT | Manojit Pal Kishore Parsa | 2014-2016 | Completed |
| Identifying and characterizing noncoding RNA regulators of chromatin in S.pombe | SERB | Aarti Sevilimedu | 2014-2017 | Completed |
| Synthesis of nitrogen containing heterocycles via multicomponent reactions (MCRs) and their evaluation against pharmacological targets. | CSIR | Manojit Pal Kishore Parsa | 2014-2017 | Completed |
| Hybrid Natural Products to Hunt for Functional Small Molecules | SERB | Prabhat Arya | 2015-2018 | Completed |
| Elucidation of PHLPP1 signaling during macrophage activation: Requirement of domains and identification of stimulus specific interaction partners | CSIR | Kishore Parsa Kiranam Chatti | 2015-2018 | Completed |
| Chemistry and Biology of Protein Tyrosine Phosphatases | Canada-Israel Joint Initiative | Ari Elson Weizmann Institute, Israel Prabhat Arya | 2016-2019 | Completed |
| Latrunculin and Eribulin Sub-structures Derived Macrocyclic Toolbox | MoES | Prabhat Arya Kiranam Chatti | 2016-2019 | Completed |
| Investigation of the regulatory role of miR-712 in inflammation induced skeletal muscle insulin resistance | SERB | Kishore Parsa Parimal Misra Sriram Seshadri (Nirma University) | 2016-2019 | Completed |
| Universal Polymer Matrix for the Synthesis of Catalytically Active Nanocomposites. Active Nanocomposites Embedded into Hyperbranched Polymer Matrix as Green and Reusable Catalysts for Diverse Catalytic Transformations. | DST | Manojit Pal Marina Rajadurai Zinaida Shifrina Nina Kuchkina (INEOS Russia) |
2016-2018 | Completed |
| Expertise in Advanced Organic Synthesis and Med Chem | Karolinska Institute, Sweden | Prabhat Arya | 2016-2018 | Completed |
| Elucidating the molecular links between nutrition, reproduction, and aging | DST-INSPIRE | Manjunatha Thondamal | 2016-2021 | Transferred (PI relocation) |
| A mechanistic study of the recruitment of the nuclear RNAi machinery for de novo establishment of heterochromatin domains in S.pombe. | DBT | Aarti Sevilimedu Kiranam Chatti | 2016-2019 | Completed |
| Understanding the functional role of ser/thr phosphatase PHLPP in inflammation/ER stress induced insulin resistance | DBT | Kishore Parsa Parimal Misra Prakash Babu (UoH) | 2016-2019 | Completed |
| Understanding the functional role of co-activator binding protein in myogenesis | SERB | Parimal Misra Kishore Parsa | 2017-2020 | Completed |
| Novel small molecules as selective and positive allosteric modulators (PAM) of 5HT2c receptor: Discovery and development of potential anti-obesity agents (F. No.VI-D&P/565/2016-17/TDT): Design and synthesis of 5HT2c agonists are undertaken for the identification of novel anti-obesity agents. | DST | Manojit Pal Parimal Misra Prem Yadav (CDRI) | 2017-2020 | Completed |
| 12R-Lipoxygenase as a target for development of drugs against psoriosis (F.No.VI-D&P/560/2016-17/TDT): Design and synthesis of 12R LOX (lipoxygenase) inhibitors are undertaken for the identification of novel agents that could be useful for the treatment of psoriasis. | DST | Manojit Pal Prof. Reddanna Nuruddin (UOH) | 2017-2020 | Completed, but 6 months no cost extension |
| Potent and selective PDE4B inhibitors for the potential treatment of arthritis | DBT | Manojit Pal Kishore Parsa Dr. Rasool (VIT) |
2018-2021 | Completed |
| Design synthesis and evaluation of novel hybrid incretins to ameliorate Type 2 Diabetes | SERB | Prasenjit Mitra Vishal Rai (IISER, Bhopal) Syed Ahamed Ibrahim (NIN) | 2018-2021 | Completed |
| Design, Synthesis and Evaluation of Novel Bioactive Peptides to Ameliorate Type 2 diabetes and Obesity | SERB | Prasenjit Mitra S. Ahmed Ibrahim (NIN) | 2018-2021 | Completed |
| Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models. | DBT | Kiranam Chatti Zeclinics | 2018-2020 | Completed |
| Synthesis of Anticancer Drug Trabectedin and Related Analogues | SERB | Ramesh Samineni | 2020-2022 | Terminated (PI relocation) |
| Design synthesis and evaluation of novel hybrid incretins to ameliorate Type 2 Diabetes | SERB | Prasenjit Mitra Vishal Rai (IISER, Bhopal) Syed Ahamed Ibrahim (NIN) | 2018-2021 | Completed |
| Design, Synthesis and Evaluation of Novel Bioactive Peptides to Ameliorate Type 2 diabetes and Obesity | SERB | Prasenjit Mitra S. Ahmed Ibrahim (NIN) | 2018-2021 | Completed |
| Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models. | DBT | Kiranam Chatti Zeclinics | 2018-2020 | Completed |
| Synthesis of Anticancer Drug Trabectedin and Related Analogues | SERB | Ramesh Samineni | 2020-2022 | Terminated (PI relocation) |
| Design synthesis and evaluation of novel hybrid incretins to ameliorate Type 2 Diabetes | SERB | Prasenjit Mitra Vishal Rai (IISER, Bhopal) Syed Ahamed Ibrahim (NIN) | 2018-2021 | Completed |
| Design, Synthesis and Evaluation of Novel Bioactive Peptides to Ameliorate Type 2 diabetes and Obesity | SERB | Prasenjit Mitra S. Ahmed Ibrahim (NIN) | 2018-2021 | Completed |
| Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models. | DBT | Kiranam Chatti Zeclinics | 2018-2020 | Completed |