Grants

The research at DRILS is supported in part by Institutional/Industry sponsorship and significantly by grants from Government agencies. Scientists at DRILS submit competitive grant proposals and routinely obtain multiple rounds of funding from agencies such as DBT, DST, SERB, ICMR and CSIR. The following is a list of current grants-

Ongoing Grants 

Title Agency PI, Co-PI’s Duration
Identification of the mechanistic basis of early striatal damage in Glutaric Aciduria Type I DBT Aarti Sevilimedu, Pushkar, Radha Rama Devi 2018-2021
Use of DNAzymes to improve CRISPR-mediated knock-in DBT GET Kiranam Chatti, Aarti Sevilimedu 2018-2021
Molecular analysis of the functional role of ser/thr phosphatase PHLPP in lipid induced formation of foam cells, a hallmark of atherosclerosis DBT Kishore Parsa, Kiranam Chatti 2019-2022
Identification of optimal therapeutic window for efficacious intervention in a Zebrafish model of Fragile X syndrome. DBT Aarti Sevilimedu, Kiranam Chatti, Pushkar Kulkarni 2019-2022
A Microneedle Transdermal Patch for Supplementing Critical Micronutrients for Prevention and Control of Anemia DBT Public Health       and Nutrition Marina Rajadurai, Parimal Misra, B.R. Shamanna, C. T. Anitha 2020-2023
Molecular characterization of the functional role of ser/thr phosphatase PHLPP in pancreatic beta cells to gain mechanistic insights into diabetes SERB Kishore Parsa
Parimal Misra, Pushkar Kulkarni, Prakash Babu (UoH)
Sasiskala M (AIG-AHF)
2020-2023
Understanding the functional role of co-activator binding   protein PIMT in adipogenesis and obesity DBT Parimal Misra, Kishore Parsa, Satyamoorthy,
Manjunath Joshi (MAHE)
2020-2023
Studies on the role of HDAC inhibitors in reprogramming cancer cell metabolism to reverse cisplatin resistance in patient derived xenograft model of ovarian cancer. ICMR Prasenjit Mitra, Manjunath Joshi, Naveena AN Kumar, Vasudha Devi    (MAHE) 2021-2024
Understanding the regulatory role of co-activator binding protein PIMT in the pancreatic b-cells of diabetic animals and T3C diabetic (Chronic pancreatitis) humans DST-SERB Parimal Misra, Kishore Parsa, Partha Chakrabarti (IICB, Kolkata), Sasikala M (AIG) 2021-2024
Center for Rare Disease Diagnosis, Research and Training IndiaAlliance/Wellcome-DBT Aarti Sevilimedu, Girisha KM (MAHE), Dr. Akhilesh Pandey (IOB ), 2021-2026

Completed Grants 

Title Agency PI, Co-PI’s Duration Status
Virtual Centre of Excellence: Multi-disciplinary approaches aimed at intervention of Mycobacterium tuberculosis DBT Seyed E. Hasnain (UoH) 2008-2013 Completed
Small molecule inhibitors of mycobacterial menaquinone biosynthetic pathway enzymes as novel anti – tubercular agents CSIR Anil K.Krutiventi, Ritta Mathew 2009-2011   Completed
Virtual Centre of Excellence on Multidisciplinary approaches aimed at interventions against Mycobacterium tuberculosis (Phase 1), Project: Molecular inhibitors targeting essential enzymes like Chorismate mutase as potential new drug(s). DBT Manojit Pal
Parimal Misra
Seyed E Hasnain
2009-2014 Completed
Phosphoproteomic analysis of tyrosine kinase signaling DST (SERB) Kiranam Chatti 2009-2012 Completed
Investigating the role of 9-O-acetylated sialic acids during early embryonic development DST (SERB) Anilkumar Challa 2009-2012 Terminated (PI relocation)
Identification and Characterization of PTEN regulators DBT Subba Reddy Maddika 2009-2012 Transferred (PI relocation)
Design, Synthesis, and Biological Evaluation of Pharmaceutically Acceptable PTP-1B Inhibitors DST (SERB) Sreedhara Voleti,  Ghanshyam Swarup (CCMB) 2010-2013   Completed
Dual Conjugation of Cationic Lipids and Cell Penetrating Peptides to dsRNA Oligonucleotides for In Vivo siRNA Delivery DBT Prasenjit Mitra, Rajamohan Poondra, Pradeep Kumar P (IIT-B) 2010-2013   Completed
Study the role of protein tyrosine phosphatase non-receptor type 18 (PTPN 18) in regulation of localization of histone deacetylase 4 (HDAC4) DST (SERB) Arunasree Kalle 2010-2013  Terminated (PI relocation)
Embryonic zebrafish as a model system to study the expression and role of breast tumour kinase DBT Kiranam Chatti 2010-2013 Completed
Understanding the role of PHLPP in IFNγ-mediated innate immune responses  of macrophages DBT Kishore Parsa       Nasreen Ehtesham    Seyed E Hasnain (IIT-D) 2010-2013 Completed
Molecular analysis of the role of PHLPP1 in macrophage inflammatory response CSIR Kishore Parsa 2010-2013 Completed
Rational design and synthesis of novel antibiotics against drug resistant bacteria DST (SERB) Marina S. Rajadurai 2010-2013 Completed
Palladium mediated synthesis of heterocyclic compounds of potential biological interest DST (SERB) Manojit Pal        Rajmohan P 2010-2013 Completed
A Chemical Biology Approach to Discover Allosteric Modulators of Glucagon Like Peptide-1 Receptor (GLP-1R) DST (SERB) Prabhat Arya        Prasenjit Mitra 2010-2013 Completed
Synthesis of novel drug-like scaffolds by diastereoselective intra-molecular aza-Diels-Alder cyclization based on α-aminoacid and vanillin precursors DST (SERB) Neelima D. Tangellamudi 2010-2013 Completed
Design, synthesis and identification of phosphodiesterase 4 (PDE4) inhibitors possessing improved safety profile DBT Manojit Pal               Kishore Parsa 2010-2011 Completed
A Suppressor screen to uncover novel functions of fission yeast S.pombe sirtuin Hst4 DBT Devyani Haldar 2010-2013 Completed
Understanding the Transcriptional Regulation and Identification of global regulators of PE/PPE genes of Mycobacterium tuberculosis DBT Vaibhav Vindal (UoH)       K. Mohareer 2011-2013   Completed
Development of Nature-Inspired Small Molecules to Modulate Prostaglandin Pathway: Exploration of  Haematopoietic Stem Cell Biology in Zebrafish DST (SERB) Rajamohan Poondra, Kiranam Chatti 2011-2014 Completed
Identification of novel Akt-interacting partners and investigation of their role in LPS-induced macrophage inflammatory response DAE Kishore Parsa 2011-2014 Completed
Understanding the role of transcriptional co-activator binding protein PIMT in the control of hepatic gluconeogenesis DBT Parimal Misra        Kishore Parsa 2011-2014 Completed
Synthesis of Fluorescent Saccharide Sensors as Potential Tool for the Diagnosis of Carbohydrate Metabolism Disorders CSIR Marina S. Rajadurai 2011-2014 Completed
A yeast based screen for discovery of novel sirtuin inhibitors as anti-cancer agents DBT Devyani Haldar       Manojit Pal 2011-2013 Completed
A Chemical Biology Approach to Discover Allosteric Modulators of Sirtuins and to Understand their Mode of Action DBT Prabhat Arya         Parimal Misra      Arunasree K 2011-2013 Completed
Development of a noninvasive method using saliva from patients for detection of a early onset of type 2 diabetes ICMR Prasenjit Mitra               S. Ahmed Ibrahim (NIN) Anupama Row (UoH) 2011-2013 Completed
Regulation of Breast Tumour Kinase (BRK) activity by its alternately spliced form lm5 CSIR Kiranam Chatti 2011-2012 Completed
Molecular analysis of the functional role of miR-7 in β-cells DST (SERB) Kishore Parsa 2012-2015 Completed
Identification of quorum sensing regulators in Mycobacterium tuberculosis DST (SERB) Krishnaveni Mohareer 2012-2015 Completed
Natural product-inspired macrocyclic architectures: Novel therapeutic agents in medicinal chemistry DST (SERB) Naveen Mulakayala 2012-2015 Terminated (PI relocation)
Understanding Cut4 and PknA phosphorylation in biofilms of Mycobacteria DST (SERB) Ritta Mathew 2012-2015 Transferred (PI relocation)
Developing and validating a single protocol based zebrafish model for preclinical safety assessment of nanotherapeutics DBT Pushkar Kulkarni     Kiranam Chatt 2013-2016 Completed
Synthesis of marine natural products based compounds of potential biological significances MoES Manojit Pal                     J. Iqbal                    Rajmohan Poondra 2013-2014 Completed
Understanding the functions of Selective AMPKγ Modulators (SAMPKγM) in dissecting the pharmacological role of different AMPK isozymes in metabolic diseases DBT Parimal Misra      Rajmohan Poondra Sreedhara R Voleti 2014-2017 Completed
Design and development of novel phosphodiesterase 4 (PDE4) inhibitors DBT Manojit Pal                Kishore Parsa 2014-2016 Completed
Identifying and characterizing noncoding RNA regulators of chromatin in S.pombe SERB Aarti Sevilimedu 2014-2017 Completed
Synthesis of nitrogen containing heterocycles via multicomponent reactions (MCRs) and their evaluation against pharmacological targets. CSIR Manojit Pal                Kishore Parsa 2014-2017 Completed
Hybrid Natural Products to Hunt for Functional Small Molecules SERB Prabhat Arya 2015-2018 Completed
Elucidation of PHLPP1 signaling during macrophage activation: Requirement of domains and identification of stimulus specific interaction partners CSIR Kishore Parsa         Kiranam Chatti 2015-2018 Completed
Chemistry and Biology of Protein Tyrosine Phosphatases Canada-Israel Joint Initiative Ari Elson                        Weizmann Institute, Israel Prabhat Arya 2016-2019 Completed
Latrunculin and Eribulin Sub-structures Derived Macrocyclic Toolbox MoES Prabhat Arya           Kiranam Chatti 2016-2019 Completed
Investigation of the regulatory role of miR-712 in inflammation induced skeletal muscle insulin resistance SERB Kishore Parsa                Parimal Misra             Sriram Seshadri (Nirma University) 2016-2019 Completed
Universal Polymer Matrix for the Synthesis of Catalytically Active Nanocomposites. Active Nanocomposites Embedded into Hyperbranched Polymer Matrix as Green and Reusable Catalysts for Diverse Catalytic Transformations. DST Manojit Pal                Marina Rajadurai
Zinaida Shifrina              Nina Kuchkina (INEOS Russia)
2016-2018 Completed
Expertise in Advanced Organic Synthesis and Med Chem Karolinska Institute, Sweden Prabhat Arya 2016-2018 Completed
Elucidating the molecular links between nutrition, reproduction, and aging DST-INSPIRE Manjunatha Thondamal 2016-2021 Transferred (PI relocation)
A mechanistic study of the recruitment of the nuclear RNAi machinery for de novo establishment of heterochromatin domains in S.pombe. DBT Aarti Sevilimedu       Kiranam Chatti 2016-2019 Completed
Understanding the functional role of ser/thr phosphatase PHLPP in inflammation/ER stress induced insulin resistance DBT Kishore Parsa           Parimal Misra           Prakash Babu (UoH) 2016-2019 Completed
Understanding the functional role of  co-activator binding protein in myogenesis SERB Parimal Misra           Kishore Parsa 2017-2020 Completed
Novel small molecules as selective and positive allosteric modulators (PAM) of 5HT2c receptor: Discovery and development of potential anti-obesity agents (F. No.VI-D&P/565/2016-17/TDT): Design and synthesis of 5HT2c agonists are undertaken for the identification of novel anti-obesity agents. DST Manojit Pal               Parimal Misra              Prem Yadav (CDRI) 2017-2020 Completed
12R-Lipoxygenase as a target for development of drugs against psoriosis (F.No.VI-D&P/560/2016-17/TDT): Design and synthesis of 12R LOX (lipoxygenase) inhibitors are undertaken for the identification of novel agents that could be useful for the treatment of psoriasis. DST Manojit Pal                  Prof. Reddanna               Nuruddin (UOH) 2017-2020 Completed, but 6 months no cost extension
Potent and selective PDE4B inhibitors for the potential treatment of arthritis DBT Manojit Pal               Kishore Parsa
Dr. Rasool (VIT)
2018-2021 Completed
Design synthesis and evaluation of novel hybrid incretins to ameliorate Type 2 Diabetes SERB Prasenjit Mitra            Vishal Rai (IISER, Bhopal) Syed Ahamed Ibrahim (NIN) 2018-2021 Completed
Design, Synthesis and Evaluation of Novel Bioactive Peptides to Ameliorate Type 2 diabetes and Obesity SERB Prasenjit Mitra                   S. Ahmed Ibrahim (NIN) 2018-2021 Completed
Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models. DBT Kiranam Chatti        Zeclinics 2018-2020 Completed
Synthesis of Anticancer Drug Trabectedin and Related Analogues SERB Ramesh Samineni 2020-2022 Terminated (PI relocation)
Design synthesis and evaluation of novel hybrid incretins to ameliorate Type 2 Diabetes SERB Prasenjit Mitra            Vishal Rai (IISER, Bhopal) Syed Ahamed Ibrahim (NIN) 2018-2021 Completed
Design, Synthesis and Evaluation of Novel Bioactive Peptides to Ameliorate Type 2 diabetes and Obesity SERB Prasenjit Mitra                   S. Ahmed Ibrahim (NIN) 2018-2021 Completed
Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models. DBT Kiranam Chatti        Zeclinics 2018-2020 Completed
Synthesis of Anticancer Drug Trabectedin and Related Analogues SERB Ramesh Samineni 2020-2022 Terminated (PI relocation)
Design synthesis and evaluation of novel hybrid incretins to ameliorate Type 2 Diabetes SERB Prasenjit Mitra            Vishal Rai (IISER, Bhopal) Syed Ahamed Ibrahim (NIN) 2018-2021 Completed
Design, Synthesis and Evaluation of Novel Bioactive Peptides to Ameliorate Type 2 diabetes and Obesity SERB Prasenjit Mitra                   S. Ahmed Ibrahim (NIN) 2018-2021 Completed
Generation of transgenic zebrafish expressing human tyrosine kinase mutants as human glioma (brain cancer) models. DBT Kiranam Chatti        Zeclinics 2018-2020 Completed