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Zebrafish Models
Established and characterized models for several well-studied rare genetic diseases
Focused research on in depth mechanistic studies as well as therapy development is underway.
Involved in establishing disease-gene association by way of functional studies in cell line based and zebrafish models in collaborative mode with clinical partners.
Successfully completed disease-gene association in CCN2, mRPS2, EXOC6B
Therapeutic platforms
mRNA and AAV platforms for gene replacement
CRISPR-based gene editing
Model creation
Multiple gene editing strategies to develop specific models in cell lines and zebrafish.
Established routine workflows for knockout generation.
Optimizing protocols for introduction of specific mutations with high efficiency.
Reporter lines
We create reporter lines in zebrafish using tol2 transgenesis to study specific cell types or organs during development in various models. Same strategy is being used for overexpression of genes of interest..
Presently generating a group of lines that can specifically be used to study mitochondrial and ER functions (number, ROS, mitophagy, ER stress).