A focused platform that has been conceptualized to showcase IP-focused technologies developed either exclusively at DRILS or through strategic collaborations
EMBRYONIC ZEBRAFISH MODELS USING DNAZYME MEDIATED KNOCKDOWN (PCT/IB2019/051255)
DNAzymes are DNA oligonucleotides that possess catalytic activity. They are synthetic and are not known to exist in nature. One application of DNAzymes is the selective degradation of RNA, which leads to transient knockdown of gene expression. This technology involves the use of DNAzymes to induce gene knockdowns in zebrafish embryos, and is protected by a patent. The method of reducing gene expression in a target zebrafish embryo via administration of one or more DNAzymes into the zebrafish embryo, and chemical modifications of the DNAzymes are claimed in our patent. This technology allows the use of DNAzymes to create zebrafish models of a range of monogenic and polygenic diseases driven by loss of gene function.
PROCESS FOR THE SYNTHESIS OF DEUTERATED CAPSAICIN, CAPSAICINOIDS AND SYNTHETIC CAPSAICIN ANALOGS (IN Granted: 466705) (PCT/IB2020/056938)
The present application provides novel processes for the synthesis of deuterated intermediates of capsiacinoids, particularly II, III, IV and V of capsiacinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V
PROCESS FOR THE PREPARATION AND IDENTIFICATION OF DEUTERATED EUGENOL (PCT/IB2020/055764)
The present invention provides a novel, simple, unique and viable processes for the synthesis of deuterium incorporated eugenols, such as deuterated eugenol (II), regioisomeric deuterated eugenol (III), and deuterated variant of methyl eugenol (V)
CONTINUOUS FLOW PROCESS FOR THE PREPARATION OF POLYMERIZABLE CATIONIC MONOMER DERIVATIVES AND PRECURSORS THEREOF (IN complete filed)
The present application relates to the industrial process for the preparation of an acrylate based polymerizable quaternary ammonium cationic monomers using continuous flow chemistry technology thereof. These cationic monomers are crucial building blocks for the preparation of polymers that are used for flocculating agents, fluorescent photo functional materials, ionogels and stimuli responsive materials, drug delivery, gene delivery, tissue engineering, and solvents or electrolytes in energy storage devices etc.