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EMBRYONIC ZEBRAFISH MODELS USING DNAZYME MEDIATED KNOCKDOWN (PCT/IB2019/051255)
DNAzymes are DNA oligonucleotides that possess catalytic activity. They are synthetic and are not known to exist in nature. One application of DNAzymes is the selective degradation of RNA, which leads to transient knockdown of gene expression. This technology involves the use of DNAzymes to induce gene knockdowns in zebrafish embryos, and is protected by a patent. The method of reducing gene expression in a target zebrafish embryo via administration of one or more DNAzymes into the zebrafish embryo, and chemical modifications of the DNAzymes are claimed in our patent. This technology allows the use of DNAzymes to create zebrafish models of a range of monogenic and polygenic diseases driven by loss of gene function.