Assoc Principal Res Scientist, CIMPS

Research Area:

Using GPU-Enabled Advanced Computation, Free energy Simulations, Computer-Aided Drug Discovery and Data-driven Computational Biology, we primarily work in the following area:

  • Conformational Dynamics and Allosteric Regulation of Protein
  • Hydration Dynamics of Protein and Peptides
  • Antibody engineering
  • Anti-viral Drug Discovery
  • Polymer self-assembly
  • System’s Pharmacology

Education & Training:

  • 2016: PhD in Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata, India.
  • 2006: Master’s in Bioinformatics, West Bengal University of Technology, Kolkata, India.

Professional Experience:

  • 2011-2012: Research Assistant, Laboratory of Computational Biophysics & Bioengineering, Department of Physics, Tougaloo College, Mississippi, U.S.A
  • 2016-2020: Postdoctoral Fellow, School of Chemical Sciences, Indian Associations for the Cultivation of Science, India
  • 2020-2022: Assistant Professor (Grade II), Amity University, Kolkata
  • 2022 Onwards: Associate Principal Research Scientist, CIMPS, Dr. Reddy’s Institute of Life Sciences
  • 2022 Onwards: Academic Editor, PLOS ONE
  • 2018 Onwards: Associate Editorial Board Member, Mini Reviews in Medicinal Chemistry

Research Interests:

Major Publications:

  • E484K and N501Y SARS-CoV 2 Spike Mutants Increase ACE2 Recognition but Reduce Affinity for Neutralizing Antibody. Sandipan Chakraborty.* International Immunopharmacology, (2022) 102, 108424
  • Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer’s disease therapeutics. Sandipan Chakraborty*, Jyotirmoy Rakshit, Jaya Bandyopadhyay*, Soumalee Basu*. International Journal of Biological Macromolecules. (2021), 176, 315-324
  • Novel mechanism of cholesterol transport by ABCA5 in macrophages and its role in dyslipidaemia. Aleepta Guha Ray, Kamalika Roy Choudhury, Sandipan Chakraborty, Devasmita Chakravarty, Vivek Chander, Biman Jana, Khawer N Siddiqui, Arun Bandyopadhyay. Journal of Molecular Biology, (2020) 432, 17, 4922-4941
  • Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes. Manish Debnath, Sandipan Chakraborty, Y Pavan Kumar, Ritapa Chaudhuri, Biman Jana, Jyotirmayee Dash. Nature Communications, (2020), 14691, 1-12
  • Targeted DNA oxidation and trajectory of radical DNA using DFT based QM/MM dynamics. Pradip Biswas, Sandipan Chakraborty. Nucleic Acid Research, (2019), 47, 2757-2765

Link to Google Scholar page: