Research Area:
Using GPU-Enabled Advanced Computation, Free energy Simulations, Computer-Aided Drug Discovery and Data-driven Computational Biology, we primarily work in the following area:
- Conformational Dynamics and Allosteric Regulation of Protein
- Hydration Dynamics of Protein and Peptides
- Antibody engineering
- Anti-viral Drug Discovery
- Polymer self-assembly
- System’s Pharmacology
Education & Training:
- 2016: PhD in Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, Kolkata, India.
- 2006: Master’s in Bioinformatics, West Bengal University of Technology, Kolkata, India.
Professional Experience:
- 2011-2012: Research Assistant, Laboratory of Computational Biophysics & Bioengineering, Department of Physics, Tougaloo College, Mississippi, U.S.A
- 2016-2020: Postdoctoral Fellow, School of Chemical Sciences, Indian Associations for the Cultivation of Science, India
- 2020-2022: Assistant Professor (Grade II), Amity University, Kolkata
- 2022 Onwards: Associate Principal Research Scientist, CIMPS, Dr. Reddy’s Institute of Life Sciences
- 2022 Onwards: Academic Editor, PLOS ONE
- 2018 Onwards: Associate Editorial Board Member, Mini Reviews in Medicinal Chemistry
Research Interests:
Major Publications:
- E484K and N501Y SARS-CoV 2 Spike Mutants Increase ACE2 Recognition but Reduce Affinity for Neutralizing Antibody. Sandipan Chakraborty.* International Immunopharmacology, (2022) 102, 108424
- Multi-target inhibition ability of neohesperidin dictates its neuroprotective activity: Implication in Alzheimer’s disease therapeutics. Sandipan Chakraborty*, Jyotirmoy Rakshit, Jaya Bandyopadhyay*, Soumalee Basu*. International Journal of Biological Macromolecules. (2021), 176, 315-324
- Novel mechanism of cholesterol transport by ABCA5 in macrophages and its role in dyslipidaemia. Aleepta Guha Ray, Kamalika Roy Choudhury, Sandipan Chakraborty, Devasmita Chakravarty, Vivek Chander, Biman Jana, Khawer N Siddiqui, Arun Bandyopadhyay. Journal of Molecular Biology, (2020) 432, 17, 4922-4941
- Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes. Manish Debnath, Sandipan Chakraborty, Y Pavan Kumar, Ritapa Chaudhuri, Biman Jana, Jyotirmayee Dash. Nature Communications, (2020), 14691, 1-12
- Targeted DNA oxidation and trajectory of radical DNA using DFT based QM/MM dynamics. Pradip Biswas, Sandipan Chakraborty. Nucleic Acid Research, (2019), 47, 2757-2765
Link to Google Scholar page: