Research area :
- Medicinal Chemistry in the area of (1) Obesity, (5HT2c agonists) (2) tuberculosis (Chorismate mutase inhibitors) (3) psoriasis (12R-LOX inhibitors), (4) inflammation (PDE-4 inhibitors) etc.
Education & Training :
- 1989: MSc in Chemistry from IIT, Kharagpur, India
- 1995: Ph.D. in Chemistry from Indian Association for the cultivation of Science / Jadavpur University, Kolkata, India
Professional Experience :
- 1995-1997 : Research Officer at Microbial R&D, Alembic Chemical Works Co Ltd., Vadodara, Gujarat, India
- 1997-1998 : Executive – Organic Synthesis at Sun Pharma Advanced Research Center, Vadodara, Gujarat, India
- 1998-2001 : Senior Scientist at Discovery-Chemistry-Synthesis, Dr. Reddy’s Research Foundation, Hyderabad, India
- 2001-2003 : Principal Scientist at Discovery-Chemistry-Synthesis, Dr. Reddy’s Research Foundation, Hyderabad, India
- 2003-2005 : Associate Director at Discovery-Chemistry-Synthesis, Dr. Reddy’s Laboratories Limited, Hyderabad, India
- 2005-2006 : Research Director at Discovery-Chemistry-Synthesis, Dr. Reddy’s Laboratories Limited, Hyderabad, India
- 2006-2007 : Principal Research Investigator(Sr. Director) at Discovery-Chemistry-Synthesis, Dr. Reddy’s Laboratories Limited, Hyderabad, IN
- 2007-2009 : Administrative Head & Senior General Manager at New Drug Discovery Dept, Matrix/Mylan laboratories Ltd, Hyderabad, IN
- 2009-2013 : Head of the Department at Organic & Medicinal Chemistry, Institute of Life Science, Hyderabad, India.
- 2012-2018 : Dean of Academic Research & Development at Organic & Medicinal Chemistry, Dr. Reddy’s Institute of Life Science, Hyderabad, IN
- 2013- : Professor at CIMPS, Dr. Reddy’s Institute of Life Science, Hyderabad, India.
- 2018- : Chief Scientist at CIMPS, Dr. Reddy’s Institute of Life Science, Hyderabad, India.
Other Affiliations :
- 2015- : Associate Editor: Chemical Biology and Medicinal at Royal Society of Chemistry, Cambridge, UK
- 2018- : Adjunct Faculty at Dept of Pharmaceutical Chemistry at Manipal Academy of Higher Education, Manipal, Karnataka, India
- 2019- : Editorial Board member at Bioorganic Chemistry, Elsevier
Research Interests :
His research interest include the design and synthesis of new chemical entities in the in the area of
- Obesity, (5HT2c agonists)
- tuberculosis (Chorismate mutase inhibitors)
- psoriasis (12R-LOX inhibitors)
- inflammation (PDE-4 inhibitors) and
- cancer (sirtuin inhibitors).
In order to fulfil these goals his team is engaged in pursuing reasearch activities in various areas of organic synthesis e.g.
- heterocyclic chemistry
- transition metal / lanthanides /rare earth / clay catalyzed reactions
- multi-component reactions
- green chemistry – zip / domino / cascade reactions, C-H/amino group activation
- Ultrasound assisted reactions
- synthesis of compounds related to natural products etc
Publications :
- G. S. Reddy, K. A. Hossain, J. S. Kumar, B. Thirupataiah, R. K. Edwin, V. B. Giliyaru, R. C. Hariharapura, G. G. Shenoy, P. Misra, M. Pal, Novel isatin-indole derivatives as potential inhibitors of chorismate mutase (CM): their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd-Cu catalysis. RSC Advances 2020, 10, 289, doi: 10.1039/c9ra09236f
- B. Thirupataiah, G. S. Reddy, S. S. Ghule, J. S. Kumar, G. Mounika, K. A. Hossain, J. Mudgal, J. E. Mathew, G. G. Shenoy, K. V. L. Parsa, M. Pal, Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring / FeCl3-mediated intramolecular arene-allyl cyclization: first identification of a benzo[c]phenanthridine based PDE4 inhibitor. Bioorg. Chem. 2020, 97, 103691 https://doi.org/10.1016/j.bioorg.2020.103691
- J. S. Kumar, B. Thirupataiah, R. Medishetti, A. Ray, S. D. Bele, K. A. Hossain, G. S. Reddy, R. K. Edwin, A. Joseph, N. Kumar, G. G. Shenoy, C. M. Rao, M. Pal, Rosuvastatin based novel 3-substituted isocoumarins / 3-alkylidenephthalides: Ultrasound assisted synthesis and identification of new anticancer agents. European Journal of Medicinal Chemistry 2020, 201, 112335; https://doi.org/10.1016/j.ejmech.2020.112335
Link to Google Scholar Page :